The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 07, 2009
Filed:
Sep. 12, 2002
Shigeyuki Yokoyama, Kanagawa, JP;
Hideo Ogiso, Kanagawa, JP;
Mikako Shirouzu, Kanagawa, JP;
Osamu Nureki, Kanagawa, JP;
Ryuichiro Ishitani, Kanagawa, JP;
Kazuki Saito, Chiba, JP;
Shigeyuki Yokoyama, Kanagawa, JP;
Hideo Ogiso, Kanagawa, JP;
Mikako Shirouzu, Kanagawa, JP;
Osamu Nureki, Kanagawa, JP;
Ryuichiro Ishitani, Kanagawa, JP;
Kazuki Saito, Chiba, JP;
Japan Science and Technology Agency, Saitama, JP;
Riken, Saitama, JP;
Mochida Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating EGFR activity, structure coordinates of these crystals, a method for screening for the substance regulating EGFR activity, a method for designing the substance regulating EGFR activity, a method for designing an EGFR variant or an EGF variant, a method for producing an EGFR variant or an EGF variant and an EGF variant or an EGFR variant obtainable by such method, a method for designing an epitope using the structure coordinates of the EGF-EGFR complex, a method for producing an anti-EGFR antibody or an anti-EGF antibody and an antibody obtainable by such method, a polypeptide or a salt thereof comprising a region that forms an EGFR dimerization site, and the like.