The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 31, 2009
Filed:
Feb. 18, 2003
Joel Moss, Bethesda, MD (US);
Rodney L. Levine, Rockville, MD (US);
Akihiro Wada, Nagasaki, JP;
Toshiya Hirayama, Nagasaki, JP;
Gregorino Paone, Rome, IT;
Joel Moss, Bethesda, MD (US);
Rodney L. Levine, Rockville, MD (US);
Akihiro Wada, Nagasaki, JP;
Toshiya Hirayama, Nagasaki, JP;
Gregorino Paone, Rome, IT;
Abstract
This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method is provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.
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