The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2009
Filed:
Feb. 22, 2007
Simone Ottonello, Parma, IT;
Nadia Moretto, Parma, IT;
Bruno Pietro Imbimbo, Parma, IT;
Gino Villetti, Parma, IT;
Simone Ottonello, Parma, IT;
Nadia Moretto, Parma, IT;
Bruno Pietro Imbimbo, Parma, IT;
Gino Villetti, Parma, IT;
Chiesi Farmaceutici S.p.A., Parma, IT;
Abstract
The present invention provides a recombinant immunogenic obtained by tandem multimerization of a B-cell epitope bearing fragment of Aβ42, within the active loop site of a carrier (display site), preferably bacterial thioredoxin (Yrx). Polypeptides bearing multiple copies of Aβ42 fragments, preferably with an interposed amino acid linker, were constructed and injected into mice in combination with an adjuvant. Elicited antibodies were found to selectively bind to fibrillar and/or oligomers Aβ within neuritic AD plaques.