The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 10, 2009

Filed:

Mar. 03, 2006
Applicants:

Daisuke Ejima, Kawasaki, JP;

Ryosuke Yumioka, Kawasaki, JP;

Tsutomu Arakawa, Thousand Oaks, CA (US);

Inventors:

Daisuke Ejima, Kawasaki, JP;

Ryosuke Yumioka, Kawasaki, JP;

Tsutomu Arakawa, Thousand Oaks, CA (US);

Assignee:

Ajinomoto Co., Inc., Tokyo, JP;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/08 (2006.01); C07K 1/10 (2006.01); C07K 1/16 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A method to more quantitatively recover a peak of a protein and associated aggregates, hydrophobic proteins, or hydrophobic peptides which are typically difficult to recover and detect as a peak, using a commercially available gel filtration chromatography column and a mobile phase is described. More specifically, a compound, such as arginine, which may be added to the mobile phase, thereby eliminating the unnecessary interaction that occurs between the proteins, peptides, or aggregates and the column stationary phase, is described.


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