The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 10, 2009

Filed:

Apr. 16, 2007
Applicants:

Jean-marc Lapierre, Pelham, NH (US);

Nivedita D. Namdev, Westford, MA (US);

Mark A. Ashwell, Carlisle, MA (US);

Dennis S. France, Carlisle, MA (US);

Hui Wu, Malden, MA (US);

Patrick M. Hutchins, Denver, CO (US);

Manish Tandon, Framingham, MA (US);

Yanbin Liu, Acton, MA (US);

Jeff S. Link, Londonderry, NH (US);

Syed M. Ali, North Andover, MA (US);

Chris J. Brassard, Somerville, MA (US);

Robb B. Nicewonger, Tyngsboro, MA (US);

Anton Filikov, Stoneham, MA (US);

Rebecca J. Carazza, Winchester, MA (US);

Inventors:

Jean-Marc Lapierre, Pelham, NH (US);

Nivedita D. Namdev, Westford, MA (US);

Mark A. Ashwell, Carlisle, MA (US);

Dennis S. France, Carlisle, MA (US);

Hui Wu, Malden, MA (US);

Patrick M. Hutchins, Denver, CO (US);

Manish Tandon, Framingham, MA (US);

Yanbin Liu, Acton, MA (US);

Jeff S. Link, Londonderry, NH (US);

Syed M. Ali, North Andover, MA (US);

Chris J. Brassard, Somerville, MA (US);

Robb B. Nicewonger, Tyngsboro, MA (US);

Anton Filikov, Stoneham, MA (US);

Rebecca J. Carazza, Winchester, MA (US);

Assignee:

ArQule, Inc., Woburn, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/04 (2006.01); C07D 513/04 (2006.01); A61K 31/429 (2006.01); A61K 31/4188 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAF. The compounds are useful for the treatment of cell proliferative disorders such as cancer.


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