The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2009
Filed:
Sep. 15, 2004
James Paul Griffith, Weston, MA (US);
James Roger Black, Wenham, MA (US);
Carlos H. Faerman, Acton, MA (US);
Lovorka Lora Swenson, Belmont, MA (US);
Michael Andrew Wynn, Salem, MA (US);
Fan LU, Newton, MA (US);
Judith A. Lippke, Chestnut Hill, MA (US);
Kumkum Saxena, Framingham, MA (US);
James Paul Griffith, Weston, MA (US);
James Roger Black, Wenham, MA (US);
Carlos H. Faerman, Acton, MA (US);
Lovorka Lora Swenson, Belmont, MA (US);
Michael Andrew Wynn, Salem, MA (US);
Fan Lu, Newton, MA (US);
Judith A. Lippke, Chestnut Hill, MA (US);
Kumkum Saxena, Framingham, MA (US);
Other;
Abstract
The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.