The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2009
Filed:
Aug. 27, 2001
Hiroshi Murakami, Tsukuba, JP;
Tatsuya Fujimura, Tsukuba, JP;
Yoichi Takahagi, Tsukuba, JP;
Koji Toyomura, Tsukuba, JP;
Tamotsu Shigehisa, Tsukuba, JP;
Hiroshi Murakami, Tsukuba, JP;
Tatsuya Fujimura, Tsukuba, JP;
Yoichi Takahagi, Tsukuba, JP;
Koji Toyomura, Tsukuba, JP;
Tamotsu Shigehisa, Tsukuba, JP;
Nippon Meat Packers, Inc., Osaka-shi, JP;
Abstract
This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding human N-acetylglucosaminyltransferase III (GnT-III), or a nonhuman transgenic mammal carrying transgene comprising the regulatory genes and genes encoding GnT-III and the human complement inhibitor. Because of reduced α-Gal antigens in the hyperacute rejection-occurring local cells or because of both reduced α-Gal antigens and expression of the human complement inhibitor, the transgenic mammal of this invention can effectively inhibit the hyperacute rejection caused by discordant xenotransplantation. Consequently, this invention provides the transgenic mammal suitable for organ transplantation.