The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2008
Filed:
Aug. 23, 2005
Duane D. Miller, Germantown, TN (US);
Bob M. Moore, Ii, Nesbit, MS (US);
Suni Mustafa, Memphis, TN (US);
Dennis R. Feller, Oxford, MS (US);
Supriya A. Bavadekar, Memphis, TN (US);
Duane D. Miller, Germantown, TN (US);
Bob M. Moore, II, Nesbit, MS (US);
Suni Mustafa, Memphis, TN (US);
Dennis R. Feller, Oxford, MS (US);
Supriya A. Bavadekar, Memphis, TN (US);
The University of Tennessee Research Foundation, Knoxville, TN (US);
The University of Mississippi, University, MS (US);
Abstract
Yohimbine derivatives are disclosed having modification of the C-16 carboxyl group to include a sidechain and where the resulting derivative does not possess a second yohimbine pharmacophore (i.e., the compound is not a yohimbine dimer). The yohimbine derivatives of the present invention are preferably characterized by selective activity as α-AR antagonists. Use of the compounds, or pharmaceutical composition containing them, for treating or preventing an αadrenergic receptor mediated condition or disorder, and for antagonizing activity of an αadrenergic receptor are also disclosed.