The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2008
Filed:
Jul. 20, 2004
Desiree H. H. Tsao, Belmont, MA (US);
Jean-baptiste Telliez, Waltham, MA (US);
Thomas Mcdonagh, Acton, MA (US);
Lih-ling Lin, Concord, MA (US);
Sang Hsu, Lexington, MA (US);
Guang-yi Xu, Medford, MA (US);
A. Karl Malakian, Boxborough, MA (US);
Desiree H. H. Tsao, Belmont, MA (US);
Jean-Baptiste Telliez, Waltham, MA (US);
Thomas McDonagh, Acton, MA (US);
Lih-Ling Lin, Concord, MA (US);
Sang Hsu, Lexington, MA (US);
Guang-Yi Xu, Medford, MA (US);
A. Karl Malakian, Boxborough, MA (US);
Genetics Institute, LLC, Cambridge, MA (US);
Abstract
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein ('N-TRADD'), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.