The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2008
Filed:
Jun. 05, 2002
Linda A. Sherman, LaJolla, CA (US);
Kimberlyn F. Card, Pembroke Pines, FL (US);
Jon A. Weidanz, Amarillo, TX (US);
Hing C. Wong, Weston, FL (US);
Elizabeth L. Thomson, Miami, FL (US);
Linda A. Sherman, LaJolla, CA (US);
Kimberlyn F. Card, Pembroke Pines, FL (US);
Jon A. Weidanz, Amarillo, TX (US);
Hing C. Wong, Weston, FL (US);
Elizabeth L. Thomson, Miami, FL (US);
Abstract
The invention provides T-cell receptor (TCR) molecules comprising a Vα chain and a Vβ chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264-272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful application including therapeutic uses and use in the detection of cells expressing p53 protein.