The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2008
Filed:
Aug. 27, 2003
Jian NI, Germantown, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
James G. Pan, Toronto, CA;
Reiner L. Gentz, Belo Horizonte-MG, BR;
Vishva M. Dixit, Los Altos Hills, CA (US);
Jian Ni, Germantown, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
James G. Pan, Toronto, CA;
Reiner L. Gentz, Belo Horizonte-MG, BR;
Vishva M. Dixit, Los Altos Hills, CA (US);
Human Genome Sciences, Inc., Rockville, MD (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.