The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2008
Filed:
Dec. 20, 2001
Applicants:
Désiré José Collen, London, GB;
Nubuo Nagai, Leuven, BE;
Yves Laroche, Brussel, BE;
Inventors:
Assignee:
Thromb-X nv, Leuven, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/18 (2006.01); C12N 15/74 (2006.01); C07H 21/04 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Vectors for the expression in yeast of mammalian plasminogen derivatives such as microplasminogen and miniplasminogen are presented. Methods for expression of these proteins in a methylotrophic yeast expression system are disclosed as well as the activation and stabilisation of the recombinant proteins. The proteins of this invention are used In the treatment of focal cerebral ischemic infarction and other thrombotic diseases.