The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2008
Filed:
Sep. 01, 2004
Juergen Roemisch, Marburg, DE;
Hans-arnold Stoehr, Wetter, DE;
Annette Feussner, Marburg, DE;
Wiegand Lang, Cölbe, DE;
Thomas Weimer, Gladenbach, DE;
Margret Becker, Marburg, DE;
Claudia Nerlich, Marburg, DE;
Gudrun Muth-naumann, Wetter, DE;
Bernd Knoblauch, Lich, DE;
Juergen Roemisch, Marburg, DE;
Hans-Arnold Stoehr, Wetter, DE;
Annette Feussner, Marburg, DE;
Wiegand Lang, Cölbe, DE;
Thomas Weimer, Gladenbach, DE;
Margret Becker, Marburg, DE;
Claudia Nerlich, Marburg, DE;
Gudrun Muth-Naumann, Wetter, DE;
Bernd Knoblauch, Lich, DE;
CSL Behring GmbH, Marburg, DE;
Abstract
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.