The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 2008
Filed:
Jan. 08, 2004
Jeffry D. Watkins, Encinitas, CA (US);
Alain P. Vasserot, Carlsbad, CA (US);
David Marquis, Encinitas, CA (US);
William D. Huse, Del Mar, CA (US);
Jeffry D. Watkins, Encinitas, CA (US);
Alain P. Vasserot, Carlsbad, CA (US);
David Marquis, Encinitas, CA (US);
William D. Huse, Del Mar, CA (US);
Applied Molecular Evolution, San Diego, CA (US);
Abstract
The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-α and that are capable of neutralizing TNF-α at low concentrations. Preferably, the TNF-α binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).