The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 2008
Filed:
Apr. 20, 2005
Alphonsus G. C. M. Uytdehaag, Vleuten, NL;
Govert Johan Schouten, Leiderdorp, NL;
Jaap Goudsmit, Amsterdam, NL;
Alphonsus G. C. M. UytdeHaag, Vleuten, NL;
Govert Johan Schouten, Leiderdorp, NL;
Jaap Goudsmit, Amsterdam, NL;
Crucell Holland B.V., Leiden, NL;
Abstract
The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived therefrom, produced on human cells, wherein the human cells comprise a sequence encoding at least one early region-1 (E1) gene product of an adenovirus. The cells are preferably cultured in suspension to very high densities and under serum-free conditions. Herein, it is disclosed that use of such cells results in high titers of West Nile Virus produced.