The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2008
Filed:
May. 26, 2003
Takashi Kadowaki, Tokyo, JP;
Toshimasa Yamauchi, Tokyo, JP;
Naoto Kubota, Tokyo, JP;
Yasuo Terauchi, Tokyo, JP;
Tetsuya Kubota, Tokyo, JP;
Tetsuo Noda, Tokyo, JP;
Ryozo Nagai, Tokyo, JP;
Yasushi Imai, Tokyo, JP;
Takashi Kadowaki, Tokyo, JP;
Toshimasa Yamauchi, Tokyo, JP;
Naoto Kubota, Tokyo, JP;
Yasuo Terauchi, Tokyo, JP;
Tetsuya Kubota, Tokyo, JP;
Tetsuo Noda, Tokyo, JP;
Ryozo Nagai, Tokyo, JP;
Yasushi Imai, Tokyo, JP;
Japan Science and Technology Agency, Kawaguchi-shi, JP;
Abstract
A scavenger receptor A expression down-regulator and a drug for preventing or treating arteriosclerosis which contain, as the active ingredient, a C-terminal globular domain of adiponectin, adiponectin, or a gene encoding the domain or adiponectin. According to the present invention, there is provided a preventive or therapeutic agent capable of directly preventing intimal thickening, which constitutes an essential feature of arteriosclerosis. This effect can be attained through arresting the onset and development of arteriosclerosis by reducing the expression level of scavenger receptor A in arterial walls and preventing lipid buildup in macrophages.