The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2008
Filed:
Apr. 12, 2005
Derrick H. Lenz, Scotch Plains, NJ (US);
Kenny C. Mok, San Diego, CA (US);
Ned S. Wingreen, Princeton, NJ (US);
Bonnie L. Bassler, Princeton, NJ (US);
Derrick H. Lenz, Scotch Plains, NJ (US);
Kenny C. Mok, San Diego, CA (US);
Ned S. Wingreen, Princeton, NJ (US);
Bonnie L. Bassler, Princeton, NJ (US);
The Trustees of Princeton University, Princeton, NJ (US);
Abstract
Quorum-sensing bacteria communicate with extracellular signal molecules called autoinducers to allow community-wide synchronization of gene expression. The present invention relates to the identification theandprotein Hfq as mediating interactions between small, regulatory RNAs (sRNAs) and specific messenger RNA (mRNA) targets. Accordingly, the present invention provides nucleic acids encoding thesRNAs, strains having various deletions and mutations of one or more qrr genes encoding these sRNA as well as methods of identifying quorum-sensing regulators. Additionally, the invention relates to an isolatedHfq protein and conservative amino acid substitutions thereof as well as nucleic acids encoding those proteins, recombinant methods of producing those proteins and antibodies against those proteins.