The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2008
Filed:
Aug. 23, 2001
Applicants:
André Trouet, Herent, BE;
Vincent Dubois, Fleurus, BE;
Alexandre Passioukov, Brussels, BE;
Inventors:
Assignee:
Medarex, Inc., Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/00 (2006.01); C07K 5/08 (2006.01); C07K 5/10 (2006.01); A61K 38/06 (2006.01); A61K 38/07 (2006.01); A61K 38/08 (2006.01); C07H 15/24 (2006.01); C07K 5/02 (2006.01); C07K 5/023 (2006.01); C07K 7/02 (2006.01); C07K 7/04 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
Abstract
The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by plasmin. Also disclosed are methods of making and using the prodrug compounds.