The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2008
Filed:
Oct. 31, 2002
Masahiko Morita, Osaka, JP;
Hiroyuki Arakawa, Osaka, JP;
Mayako Yamazaki, Osaka, JP;
Susumu Satoh, Osaka, JP;
Shintaro Nishimura, Osaka, JP;
Yasuhiro Kita, Osaka, JP;
Takao Yamazaki, Osaka, JP;
Masahiko Morita, Osaka, JP;
Hiroyuki Arakawa, Osaka, JP;
Mayako Yamazaki, Osaka, JP;
Susumu Satoh, Osaka, JP;
Shintaro Nishimura, Osaka, JP;
Yasuhiro Kita, Osaka, JP;
Takao Yamazaki, Osaka, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these proteins were found to enhance cell damage. Compounds that can be screened based on the evaluation methods of this invention are useful as agents for inhibiting the CREB dephosphorylation reaction, agents for suppressing enhancement of cell damage, and preventive and therapeutic agents for memory disorders and/or neurodegenerative disorders.