The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2008
Filed:
Jan. 11, 2002
Daisuke Kiga, Wako, JP;
Kensaku Sakamoto, Tokyo, JP;
Ichiro Hirao, Asaka, JP;
Shigeyuki Yokoyama, Tokyo, JP;
Daisuke Kiga, Wako, JP;
Kensaku Sakamoto, Tokyo, JP;
Ichiro Hirao, Asaka, JP;
Shigeyuki Yokoyama, Tokyo, JP;
Japan Science and Technology Agency, Saitama, JP;
Abstract
Tyrosyl-tRNA synthetases having a modified amino acid sequence whereby unnatural amino acids can be more efficiently incorporated than original natural amino acids. More specifically, tyrosyl-tRNA synthetases having been modified at the amino acid(s) at the 37- and/or 195-positions. A method of modifying tyrosyl-tRNA synthetase characterized in that the position of an amino acid to be modified is determined based on the 3-D structure of a tyrosyl-AMP and of tyrosyl synthetase complex and an amino acid to which this enzyme binds.