The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2008
Filed:
Oct. 15, 2004
Dana M. Fowlkes, Chapel Hill, NC (US);
James R. Broach, Princeton, NJ (US);
John P. Manfredi, Salt Lake City, UT (US);
Jeremy I. Paul, Nyack, NY (US);
Joshua Trueheart, Concord, MA (US);
Christine A. Klein, Salt Lake City, UT (US);
Andrew J. M. Murphy, Croton-on-Hudson, NY (US);
Dana M. Fowlkes, Chapel Hill, NC (US);
James R. Broach, Princeton, NJ (US);
John P. Manfredi, Salt Lake City, UT (US);
Jeremy I. Paul, Nyack, NY (US);
Joshua Trueheart, Concord, MA (US);
Christine A. Klein, Salt Lake City, UT (US);
Andrew J. M. Murphy, Croton-on-Hudson, NY (US);
Cadus Technologies, Inc., New York, NY (US);
Abstract
The present invention pertains to novel yeast cells which are useful for the expression of heterologous G protein coupled receptors. The yeast cells of the present invention can be used in screening assays which can be used to screen for modulators of G protein coupled receptors. Specifically, the invention provides novel yeast cells which express a heterologous G protein coupled receptor and mutant and/or chimeric G protein subunit molecules which serve to functionally integrate the heterologous into the pheromone signaling pathway of the yeast cell. The invention also provides for the expression of heterologous G protein coupled receptors which are functionally integrated into the yeast cell membrane using a yeast α factor leader sequence. Drug discovery assays using the subject yeast cells are also provided.