The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2008
Filed:
Mar. 29, 2006
Theodora W. Salcedo, East Syracuse, NY (US);
Steven M. Ruben, Brookeville, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Vivian R. Albert, Rockville, MD (US);
Claire Dobson, Cambridge, GB;
Tristan Vaughan, Cambridge, GB;
Theodora W. Salcedo, East Syracuse, NY (US);
Steven M. Ruben, Brookeville, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Vivian R. Albert, Rockville, MD (US);
Claire Dobson, Cambridge, GB;
Tristan Vaughan, Cambridge, GB;
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.