The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2008
Filed:
Nov. 13, 2006
Barbara Dalie, Annandale, NJ (US);
Xuedong Fan, Union, NJ (US);
Daniel Lundell, Flemington, NJ (US);
Charles A. Lunn, Somerville, NJ (US);
Jimmy C. Tan, Edison, NJ (US);
Paul J. Zavodny, Mountainside, NJ (US);
Barbara Dalie, Annandale, NJ (US);
Xuedong Fan, Union, NJ (US);
Daniel Lundell, Flemington, NJ (US);
Charles A. Lunn, Somerville, NJ (US);
Jimmy C. Tan, Edison, NJ (US);
Paul J. Zavodny, Mountainside, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-α. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-α convertases, and for identifying nucleic acids encoding such convertases.