The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2008
Filed:
Aug. 30, 1999
Merl F. Hoekstra, Cardiff-by-the-sea, CA (US);
Weilin Xie, San Diego, CA (US);
Brion W. Murray, San Diego, CA (US);
Frank M. Mercurio, Del Mar, CA (US);
Merl F. Hoekstra, Cardiff-by-the-sea, CA (US);
Weilin Xie, San Diego, CA (US);
Brion W. Murray, San Diego, CA (US);
Frank M. Mercurio, Del Mar, CA (US);
Signal Pharmaceuticals, San Diego, CA (US);
Abstract
Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF-β) and members of the TGF-β family, such as bone morphogenic protein (BMP). Such agents may be identified using screens that evaluate candidate agents for the ability to modulate Smad protein degradation. Agents identified as described herein may be used to augment or inhibit signaling mediated by one or more TGF-β family members in a variety of cell types and for therapeutic purposes.