The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2008
Filed:
Jan. 24, 2005
Thomas H. Fischer, Hillsborough, NC (US);
Marjorie S. Read, Durham, NC (US);
Arthur P. Bode, Greenville, NC (US);
Timothy C. Nichols, Chapel Hill, NC (US);
Thomas H. Fischer, Hillsborough, NC (US);
Marjorie S. Read, Durham, NC (US);
Arthur P. Bode, Greenville, NC (US);
Timothy C. Nichols, Chapel Hill, NC (US);
University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
East Carolina University, Greenvile, NC (US);
Abstract
Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.