The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2008
Filed:
Jun. 19, 2003
Andreas Gerardus Uitterlinden, Poortugaal, NL;
Johannes Petrus Thomas Maria Van Leeuwen, Amstelveen, NL;
Huibert Adriaan Pieter Pols, Papendrecht, NL;
Andreas Gerardus Uitterlinden, Poortugaal, NL;
Johannes Petrus Thomas Maria Van Leeuwen, Amstelveen, NL;
Huibert Adriaan Pieter Pols, Papendrecht, NL;
Century Technology, Inc., Wilmington, DE (US);
Abstract
In one aspect, the present invention provides methods of determining susceptibility to bone fracture in a mammalian subject, wherein the methods comprise analyzing nucleic acid molecules obtained from the mammalian subject to determine which of the P, p X, and x alleles of the estrogen receptor α gene are present, wherein the presence of a haplotype comprising the p and x alleles is indicative of an increased susceptibility to bone fracture. The present invention also provides kits for determining susceptibility to bone fracture in a mammalian subject.