The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2008
Filed:
Jan. 21, 2005
Applicants:
Igor R. Likhotvorik, Culver, IN (US);
Joseph J. Lisowski, Knox, IN (US);
Inventors:
Igor R. Likhotvorik, Culver, IN (US);
Joseph J. Lisowski, Knox, IN (US);
Assignee:
Acura Pharmaceuticals, Inc., Palatine, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention includes a process for the manufacture of dihydrothebaine, dihydrocodeinone enol acetate, hydrocodone, and analogs thereof by reacting dihydrocodeine or analogs thereof with benzophenone in the presence of potassium tert-alkylate in a hydrocarbon solvent to generate a reaction mixture containing an enolate of the corresponding ketone, followed by addition of the reaction mixture to the electrophilic agent and isolation of the product.