The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2008
Filed:
Nov. 23, 2005
Soldano Ferrone, Buffalo, NY (US);
Constantin Ioannides, Houston, TX (US);
James L. Murray, Houston, TX (US);
Kouichiro Kawano, Kurume, JP;
Soldano Ferrone, Buffalo, NY (US);
Constantin Ioannides, Houston, TX (US);
James L. Murray, Houston, TX (US);
Kouichiro Kawano, Kurume, JP;
Health Research, Inc., Buffalo, NY (US);
Board of Regents, The University of Texas Systems, Austin, TX (US);
Abstract
The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino acid sequence of an antigen to identify regions of homology between the Ab2 and the antigen, and to further identify an HLA binding motif in a homologous region. The identified homologous region which comprises an HLA binding motif defines a peptide sequence that is useful for stimulating a CTL response. Also provided are peptides identified by the method, and a method of using the peptides to stimulate a CTL response in an individual.