The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2008
Filed:
Nov. 16, 2006
Jeffrey W. Karpen, Portland, OR (US);
Thomas C. Rich, Mobile, AL (US);
Dermot M. F. Cooper, Cambridgeshire, GB;
Jerome Schaack, Denver, CO (US);
Kent Fagan, Centennial, CO (US);
Jeffrey W. Karpen, Portland, OR (US);
Thomas C. Rich, Mobile, AL (US);
Dermot M. F. Cooper, Cambridgeshire, GB;
Jerome Schaack, Denver, CO (US);
Kent Fagan, Centennial, CO (US);
The Regents of the University of Colorado, Boulder, CO (US);
Abstract
The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments, regulation by Ca-calmodulin has been removed in the modified CNG channels. Convenient optical methods for detecting changes in cAMP, taking advantage of the Capermeability of the channel are also provided by the present invention. In addition, electrophysiological methods are further provided.