The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2008
Filed:
Sep. 11, 2003
Yuji Yoshimura, Yamaguchi, JP;
Masami Yasukawa, Chiba, JP;
Syuji Morikiyo, Yamaguchi, JP;
Hiroo Matsumoto, Chiba, JP;
Yasutaka Takada, Chiba, JP;
Michiaki Adachi, Chiba, JP;
Yuji Yoshimura, Yamaguchi, JP;
Masami Yasukawa, Chiba, JP;
Syuji Morikiyo, Yamaguchi, JP;
Hiroo Matsumoto, Chiba, JP;
Yasutaka Takada, Chiba, JP;
Michiaki Adachi, Chiba, JP;
Nissan Chemical Industries, Ltd., Tokyo, JP;
Abstract
A method for producing an alkyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate of the formula (1) (wherein R is a Calkyl group), which is an intermediate for a cholesterol-reducing agent (a HMG-CoA reductase inhibitor), etc. A solution containing a compound of the formula (1) is subjected to liquid chromatography treatment using silica gel as the packing material, to separate its epimers contained therein.