The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2008
Filed:
Jan. 10, 2005
Shawn Defrees, North Wales, PA (US);
David A. Zopf, Wayne, PA (US);
Zhi-guang Wang, Dresher, PA (US);
Henrik Clausen, Holte, DE;
Shawn DeFrees, North Wales, PA (US);
David A. Zopf, Wayne, PA (US);
Zhi-Guang Wang, Dresher, PA (US);
Henrik Clausen, Holte, DE;
Neose Technologies, Inc., Horsham, PA (US);
Abstract
The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble polymer, a therapeutic agent of a biomolecule is covalently linked through an intact O-linked glycosyl residue to the polypeptide. Also provided are methods of making the peptides of the invention and methods, pharmaceutical compositions containing the peptides and methods of treating, ameliorating or preventing diseased in mammals by administering an amount of a peptide of the invention sufficient to achieve the desired response.