The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2008
Filed:
Dec. 05, 2005
George H. Searfoss, Iii, Birdsboro, PA (US);
Marco F. Pagnoni, Norristown, PA (US);
Yuri D. Ivashchenko, Norristown, PA (US);
Kun Guo, Norristown, PA (US);
Kenneth L. Clark, Stevenage, GB;
George H. Searfoss, III, Birdsboro, PA (US);
Marco F. Pagnoni, Norristown, PA (US);
Yuri D. Ivashchenko, Norristown, PA (US);
Kun Guo, Norristown, PA (US);
Kenneth L. Clark, Stevenage, GB;
sanofi-aventis U.S. LLC, Bridgewater, NJ (US);
Abstract
The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF α signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as 'TRAF2 truncated' or 'TRAF2TR' and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as “TRAF2 truncated-deleted” or “TRAF2TD”. Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF α signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF α binding.