The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2008
Filed:
Oct. 11, 2002
Leon W. M. M. Terstappen, Huntingdon Valley, PA (US);
Galla Chandra Rao, Princeton, NJ (US);
Jonathan W. Uhr, Dallas, TX (US);
Emilian V. Racila, Dallas, TX (US);
Paul A. Liberti, Huntingdon Valley, PA (US);
Leon W. M. M. Terstappen, Huntingdon Valley, PA (US);
Galla Chandra Rao, Princeton, NJ (US);
Jonathan W. Uhr, Dallas, TX (US);
Emilian V. Racila, Dallas, TX (US);
Paul A. Liberti, Huntingdon Valley, PA (US);
Immunivest Corporation, Wilmington, DE (US);
Abstract
A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivity than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells.