The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2008
Filed:
Mar. 08, 2007
Applicants:
John E. Cabaj, Sheboygan, WI (US);
Jeff J. Hutchison, Sheboygan, WI (US);
Inventors:
John E. Cabaj, Sheboygan, WI (US);
Jeff J. Hutchison, Sheboygan, WI (US);
Assignee:
Cedarburg Pharmaceuticals, Inc., Grafton, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 231/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.