The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2008
Filed:
Feb. 14, 2001
Hisashi Iizasa, Tokyo, JP;
Kenji Hattori, Kaisei-machi, JP;
Emi Nakashima, Tokyo, JP;
Tetsuya Terasaki, Sendai, JP;
Masuo Obinata, Sendai, JP;
Hisashi Iizasa, Tokyo, JP;
Kenji Hattori, Kaisei-machi, JP;
Emi Nakashima, Tokyo, JP;
Tetsuya Terasaki, Sendai, JP;
Masuo Obinata, Sendai, JP;
Japan Science and Technology Agency, Kawaguchi-Shi, Saitama, JP;
Abstract
To provide an immortalized capillary pericyte line which maintains the original function/property of the cell line-deriving tissue, its establishment method, and the screening method for useful substance using the immortalized capillary pericyte line. Cerebral tissue of a transgenic rat carrying the large T antigen gene of SV40 thermo-sensitive mutant line tsA58 is homogenized and the resultant brain capillaries are treated with protease, thus obtained brain capillary cells are subcultured to establish an immortalized cell that expresses SV40 thermo-sensitive large T antigen, PDGF receptor β, and Angiopoietin-1. In addition, the immortalized vascular pericyte line has ability to deposit calcium on matrix by dense culture.