The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2007
Filed:
Aug. 28, 2003
Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
Thomas Maciag, Freeport, ME (US);
Ann B. Zimrin, Baltimore, MD (US);
Deena J. Small, Scarborough, ME (US);
Igor A. Prudovsky, Old Orchard Beach, ME (US);
Thomas Maciag, Freeport, ME (US);
Ann B. Zimrin, Baltimore, MD (US);
Deena J. Small, Scarborough, ME (US);
Igor A. Prudovsky, Old Orchard Beach, ME (US);
Maine Medical Center Research Institute, Scarborough, ME (US);
Abstract
This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on their role in the signaling pathway relating to endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof. Further, this invention provides a substantially purified soluble Jagged protein and a substantially purified nucleic acid encoding same as well as a recombinant cell comprising a nucleic acid encoding a soluble Jagged protein. Soluble Jagged provides further therapeutic and diagnostic methods relating to diseases, disorders, and conditions involving Jagged/Notch signaling including, inter alia, angiogenesis, differentiation, and control of gene expression.