The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2007
Filed:
May. 10, 2001
Ilse Bartke, Mannheim, DE;
Jurgen Unger, Landshut, DE;
Claude Genain, Mill Valley, CA (US);
Stephen Hauser, Ross, CA (US);
Ilse Bartke, Mannheim, DE;
Jurgen Unger, Landshut, DE;
Claude Genain, Mill Valley, CA (US);
Stephen Hauser, Ross, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
This invention pertains to the discovery that nerve growth factor (NGF) is capable of preventing further demyelination of nervous tissue in pathologies characterized by the demyelination of nervous tissue (e.g. multiple sclerosis). In one embodiment, this invention provides a method for inhibiting demyelination in a subject having an inflammatory disease of a nervous tissue. The method involves administering an effective amount of NGF, an NGF analogue, or an active fragment of NGF where the effective amount is sufficient to downregulate the production of interferon λ by T cells infiltrating the central nervous system and/or to upregulate IL-10 production by glial cells.