The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 02, 2007
Filed:
Mar. 19, 2004
Kathrin U. Jansen, Doylestown, PA (US);
Loren D. Schultz, Harleysville, PA (US);
Michael P. Neeper, Collegeville, PA (US);
Henry Z. Markus, Wyncote, PA (US);
Kathrin U. Jansen, Doylestown, PA (US);
Loren D. Schultz, Harleysville, PA (US);
Michael P. Neeper, Collegeville, PA (US);
Henry Z. Markus, Wyncote, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Synthetic DNA molecules encoding the HPV31 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV31 L1 protein, wherein said polynucleotides are free from internal transcription termination signals that are recognized by yeast. Also provided are synthetic polynucleotides encoding HPV31 L1 wherein the polynucleotides have been codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV31 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV31 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity