The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2007
Filed:
Nov. 04, 2004
Applicants:
Paul Schimmel, La Jolla, CA (US);
Keisuke Wakasugi, Shizuok, JP;
Martin Friedlander, Del Mar, CA (US);
Inventors:
Paul Schimmel, La Jolla, CA (US);
Keisuke Wakasugi, Shizuok, JP;
Martin Friedlander, Del Mar, CA (US);
Assignee:
The Scripps Research Institute, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/45 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
Abstract
An isolated, water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase is useful for the inhibition of angiogenesis. The polypeptide has the amino acid residue sequence shown in SEQ ID NO: 7, SEQ ID NO: 12, or an angiogenesis inhibiting fragment thereof, the fragment including at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). Methods of using the polypeptide to inhibit angiogenesis are also provided.