The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2007
Filed:
Mar. 11, 2005
Paul J. Yazaki, Glendale, CA (US);
Mark A. Sherman, Pasadena, CA (US);
John E. Shively, Arcadia, CA (US);
Andrew A. Raubitschek, San Marino, CA (US);
Anna M. Wu, Sherman Oaks, CA (US);
Paul J. Yazaki, Glendale, CA (US);
Mark A. Sherman, Pasadena, CA (US);
John E. Shively, Arcadia, CA (US);
Andrew A. Raubitschek, San Marino, CA (US);
Anna M. Wu, Sherman Oaks, CA (US);
City of Hope, Duarte, CA (US);
Abstract
Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEA in vivo.