The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2007
Filed:
Apr. 09, 1999
Masaaki Goto, Tochigi, JP;
Akihiro Tomoyasu, Tochigi, JP;
Kazuki Yano, Tochigi, JP;
Fumie Kobayashi, Tochigi, JP;
Nobuaki Nakagawa, Tochigi, JP;
Hisataka Yasuda, Tochigi, JP;
Kyoji Yamaguchi, Saitama, JP;
Masahiko Kinosaki, Tochigi, JP;
Shin-ichi Mochizuki, Tochigi, JP;
Tadashi Nakakarumai, Tochigi, JP;
Tomonori Morinaga, Tochigi, JP;
Eisuke Tsuda, Tochigi, JP;
Kanji Higashio, Saitama, JP;
Masaaki Goto, Tochigi, JP;
Akihiro Tomoyasu, Tochigi, JP;
Kazuki Yano, Tochigi, JP;
Fumie Kobayashi, Tochigi, JP;
Nobuaki Nakagawa, Tochigi, JP;
Hisataka Yasuda, Tochigi, JP;
Kyoji Yamaguchi, Saitama, JP;
Masahiko Kinosaki, Tochigi, JP;
Shin-ichi Mochizuki, Tochigi, JP;
Tadashi Nakakarumai, Tochigi, JP;
Tomonori Morinaga, Tochigi, JP;
Eisuke Tsuda, Tochigi, JP;
Kanji Higashio, Saitama, JP;
Daiichi Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a molecular weight of about 45 kD under non-reducing conditions and about 28 kD and/or 23 kD under reducing conditions, and exhibiting affinity to heparin. A process of producing the protein comprising culturing human fibroblasts and purifying the culture broth by chromatography using an ion exchange column, affinity column, and reverse phase column. A cDNA encoding the protein and a process of producing the protein using the cDNA are also provided. The protein of the present invention is useful as a pharmaceutical composition for preventing or treating obesity or as an antigen for establishing immunological diagnosis, etc.