The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2007
Filed:
Jul. 30, 2002
Larry Cosenza, Birmingham, AL (US);
Terry L. Bray, Birmingham, AL (US);
Lawrence J. Delucas, Birmingham, AL (US);
Thomas E. Gester, Birmingham, AL (US);
David T. Hamrick, Glencoe, AL (US);
Larry Cosenza, Birmingham, AL (US);
Terry L. Bray, Birmingham, AL (US);
Lawrence J. DeLucas, Birmingham, AL (US);
Thomas E. Gester, Birmingham, AL (US);
David T. Hamrick, Glencoe, AL (US);
UAB Research Foundation, Birmingham, AL (US);
Abstract
An improved method of screening crystal growth conditions is provided wherein molecules are crystallized from solutions containing dyes. These dyes are selectively incorporated or associated with crystals of particular character thereby rendering crystals of particular character colored and improving detection of the dyed crystals. A preferred method involves use of dyes in protein solutions overlayed by oil. Use of oil allows the use of small volumes of solution and facilitates the screening of large numbers of crystallization conditions in arrays using automated devices that dispense appropriate solutions to generate crystallization trials, overlay crystallization trials with an oil, provide appropriate conditions conducive to crystallization and enhance detection of dyed (colored) or undyed (uncolored) crystals that result.