The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2007
Filed:
Dec. 12, 2003
Chung Chan, Issaquah, WA (US);
Bruce L. Zamost, Seattle, WA (US);
Douglas C. Covert, Mukilteo, WA (US);
Hong Y. Liu, Seattle, WA (US);
Karen S. DE Jongh, Seattle, WA (US);
Jeffrey D. Meyer, Lake Forest Park, WA (US);
Susan D. Holderman, Seattle, WA (US);
Chung Chan, Issaquah, WA (US);
Bruce L. Zamost, Seattle, WA (US);
Douglas C. Covert, Mukilteo, WA (US);
Hong Y. Liu, Seattle, WA (US);
Karen S. De Jongh, Seattle, WA (US);
Jeffrey D. Meyer, Lake Forest Park, WA (US);
Susan D. Holderman, Seattle, WA (US);
ZymoGenetics, Inc., Seattle, WA (US);
Abstract
The expression vectors and methods using anexpression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation inUsing the expression vectors, the IL-21 gene was produced into a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficientstrains transformed with an IL-21 expression vector.