The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2007
Filed:
May. 02, 2001
Tong Zhou, Birmingham, AL (US);
Kimihisa Ichikawa, Yokohama, JP;
Robert P. Kimberly, Birmingham, AL (US);
William J. Koopman, Indian Springs, AL (US);
Tong Zhou, Birmingham, AL (US);
Kimihisa Ichikawa, Yokohama, JP;
Robert P. Kimberly, Birmingham, AL (US);
William J. Koopman, Indian Springs, AL (US);
The UAB Research Foundation, Birmingham, AL (US);
Abstract
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.