The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2007
Filed:
Sep. 25, 2002
Toshimitsu Uede, Hokkaido, JP;
Shigeyuki Kon, Gunma, JP;
Nobuchika Yamamoto, Osaka, JP;
Hirofumi Higuchi, Kumamoto, JP;
Masaharu Torikai, Kumamoto, JP;
Yoshiyuki Tokieda, Kumamoto, JP;
Toshihiro Nakashima, Kumamoto, JP;
Hiroaki Maeda, Kumamoto, JP;
Toshimitsu Uede, Hokkaido, JP;
Shigeyuki Kon, Gunma, JP;
Nobuchika Yamamoto, Osaka, JP;
Hirofumi Higuchi, Kumamoto, JP;
Masaharu Torikai, Kumamoto, JP;
Yoshiyuki Tokieda, Kumamoto, JP;
Toshihiro Nakashima, Kumamoto, JP;
Hiroaki Maeda, Kumamoto, JP;
Juridical Foundation the Chemo-sero-therapeutic Research Institute, Kumamoto-shi, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
A recombinant antibody in which at least the constant regions in the heavy chain and the light chain have been converted into human-origin regions and which inhibits the binding of an integrin recognizing the RGD sequence to osteopontin or its fragment and inhibits the binding of an integrin recognizing the SVVYGLR sequence or a sequence corresponding thereto to osteopontin or its fragment. This antibody is useful as a remedy for autoimmune diseases and a remedy for rheumatism or rheumatoid arthritis. Thus, a method of treating autoimmune diseases, rheumatism or rheumatoid arthritis is provided. This osteopontin antibody is useful in a diagnostic for rheumatism and a method of diagnosing rheumatism too.