The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2007
Filed:
Dec. 06, 2004
Tianbo LU, Kennett Square, PA (US);
Bruce E. Tomczuk, Collegeville, PA (US);
Louis V. Lafrance, West Chester, PA (US);
Thomas P. Markotan, Morgantown, PA (US);
Juan J. Marugan Sanchez, Downingtown, PA (US);
Victor J. Marder, Los Angeles, CA (US);
David C. U'prichard, Philadelphia, PA (US);
Beth M. Anaclerio, New Castle, DE (US);
Zihong Guo, Southbury, CT (US);
Wenzi Pan, Exton, PA (US);
Kristi A. Leonard, West Chester, PA (US);
Tianbo Lu, Kennett Square, PA (US);
Bruce E. Tomczuk, Collegeville, PA (US);
Louis V. LaFrance, West Chester, PA (US);
Thomas P. Markotan, Morgantown, PA (US);
Juan J. Marugan Sanchez, Downingtown, PA (US);
Victor J. Marder, Los Angeles, CA (US);
David C. U'Prichard, Philadelphia, PA (US);
Beth M. Anaclerio, New Castle, DE (US);
Zihong Guo, Southbury, CT (US);
Wenzi Pan, Exton, PA (US);
Kristi A. Leonard, West Chester, PA (US);
3-Dimensional Pharmaceutical, Inc., Yardley, PA (US);
Abstract
The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αβand αβintegrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αβand αβintegrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R, R, R, R, R, R, R, R, R, R, R, R, R, R, D, X, W, a, m, n, i, j, k and v are defined herein.