The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Jan. 24, 2005
Jean E. F. Rivier, La Jolla, CA (US);
Jean Claude Reubi, Berne, CH;
Judit Erchegyi, San Diego, CA (US);
Roland Riek, La Jolla, CA (US);
Jean E. F. Rivier, La Jolla, CA (US);
Jean Claude Reubi, Berne, CH;
Judit Erchegyi, San Diego, CA (US);
Roland Riek, La Jolla, CA (US);
The Salk Institute for Biological Studies, San Diego, CA (US);
Abstract
Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA[Ala]-SRIF; des-AA[Aph]-SRIF, des-AA[Aph]Cbm-SRIF; des-AA[Tyr,Ala]-Cbm-SRIF, and des-AA[Tyr,CMe-L-2Nal]-SRIF, and counterparts incorporating D-Cysand/or D-Trpand/or Ala, bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.