The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Mar. 05, 2002
Gregory M. Podsakoff, Fullerton, CA (US);
Paul D. Kessler, Baltimore, MD (US);
Barry J. Byrne, Baltimore, MD (US);
Gary J. Kurtzman, Menlo Park, CA (US);
Gregory M. Podsakoff, Fullerton, CA (US);
Paul D. Kessler, Baltimore, MD (US);
Barry J. Byrne, Baltimore, MD (US);
Gary J. Kurtzman, Menlo Park, CA (US);
Genzyme Corporation, Cambridge, MA (US);
Abstract
The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of the delivered gene and for in vivo secretion of the therapeutic protein from transduced muscle cells such that systemic delivery is achieved.