The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Jul. 02, 2003
Akio Ozaki, Machida, JP;
Hideo Mori, Machida, JP;
Takeshi Shibasaki, Machida, JP;
Katsuhiko Ando, Machida, JP;
Shigeru Chiba, Kawasaki, JP;
Akio Ozaki, Machida, JP;
Hideo Mori, Machida, JP;
Takeshi Shibasaki, Machida, JP;
Katsuhiko Ando, Machida, JP;
Shigeru Chiba, Kawasaki, JP;
Kyowa Hakko Kogyo Co., Ltd., Tokyo, JP;
Abstract
The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genusorand which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. In addition, the present invention is directed to a process for producing trans-4-hydroxy-L-proline, wherein the L-proline biosynthesis activity of the host cell of the transformant is reinforced.