The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2007
Filed:
Sep. 12, 2003
Xing Su, Cupertino, CA (US);
Andrew A. Berlin, San Jose, CA (US);
Selena Chan, San Jose, CA (US);
Steven J. Kirch, Pleasanton, CA (US);
Tac-woong Koo, South San Francisco, CA (US);
Gabi Neubauer, Los Gatos, CA (US);
Valluri Rao, Saratoga, CA (US);
Narayanan Sundararajan, San Francisco, CA (US);
Mineo Yamakawa, Campbell, CA (US);
Xing Su, Cupertino, CA (US);
Andrew A. Berlin, San Jose, CA (US);
Selena Chan, San Jose, CA (US);
Steven J. Kirch, Pleasanton, CA (US);
Tac-Woong Koo, South San Francisco, CA (US);
Gabi Neubauer, Los Gatos, CA (US);
Valluri Rao, Saratoga, CA (US);
Narayanan Sundararajan, San Francisco, CA (US);
Mineo Yamakawa, Campbell, CA (US);
Intel Corporation, Santa Clara, CA (US);
Abstract
The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the release of labeled or unlabeled nucleotides that are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides released from a nucleic acid by exonuclease treatment are covalently cross-linked to nanoparticles and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus for nucleic acid sequencing.